Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
In vitro reduction of IL-1β secretion. (A) Porcine peripheral blood mononuclear cells (PBMCs) released IL-1β after administration of lipopolysaccharide (LPS) and adenosine triphosphate (ATP) in vitro. Addition of IZD334 reduced IL-1β release (n = 3). (B) Whole blood IC50 calculation after stimulation with LPS and ATP and administration of increasing concentrations of IZD334 in vitro. p-values (** <0.005, *** <0.0005) are compared to vehicle control (0 µM of IZD334).
