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One-carbon metabolism includes the methionine cycle, which is linked to the folate cycle, polyamine synthesis, and the trans-sulphuration pathway. Enzymes catalyzing significant reactions are shown in italics. Metabolite abbreviations are: SAM: S-adenosyl methionine; SAH: s-adenosyl homocysteine; dcSAM: decarboxy-s-adenosyl methionine; ROS: reactive oxygen species; THF: tetrahydrofolate; m-THF: methyl-THF; me-THF: methylene-THF; F-THF: formyl-THF.
