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Inflammatory mediators’ levels pre- and post-vaccination. (A) A significant increase in GrB serum levels was observed only in o-pwMS after vaccination (mean ± SD: 13.115 ± 4.407) compared to before (10.555 ± 3.264; p = 0.021, Student’s paired t-test), while no differences were found of (B) IFN-γ and (C) TNF-α serum levels pre- and post-vaccination in each DMT.
