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. 2022 Dec 1;10(12):3096. doi: 10.3390/biomedicines10123096

Figure 4.

Figure 4

Inhibitory effect of geniposidic acid (GPA) on mRNA induction of osteoclast differentiation-related genes. To determine the effect of GPA in osteoclast differentiation, BMMCs were cultured with sRANKL (100 ng/mL) and M-CSF (20 ng/mL) for 48 h in the presence or absence of GPA (100 or 1000 μg/mL). mRNA expression was determined using quantitative PCR ((a): OSCAR, (b): NFATc1, (c): c-Fos, (d): cathepsin K, (e): MMP-9, and (f): DC-STAMP). * Significantly higher mRNA expression of genes by Student’s t-test (* p < 0.01).