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. 2022 Nov 25;10(12):3048. doi: 10.3390/biomedicines10123048

Figure 1.

Figure 1

Homocysteine (Hcy) exacerbates renal IR-induced renal damage. C57BL/6 mice were subjected to renal ischemia for 25 min, immediately intravenously injected with saline or Hcy (0.2 mg/kg), and sacrificed 24 h after reperfusion. Blood, kidney and brain samples were collected from sham and IR mice treated with saline or Hcy (n = 12). Plasma creatinine and Hcy levels and renal expression of neutrophil gelatinase-associated lipocalin (NGAL) were determined (A–C). Kidney sections were stained with H&E and tubular damages were scored as described (D). Data are presented as the mean ± SEM. * p < 0.05 vs. sham mice; # p < 0.05 vs. IR mice. Black dots indicate individual data points. Scale bar, 100 μm.