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. 2022 Nov 29;10(12):3072. doi: 10.3390/biomedicines10123072

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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HUNK alteration in cBioPortal breast cancer datasets. (A) HUNK appeared in 8 of 24 studies and has an alteration frequency of up to 3% (1: Proteogenomic landscape of breast cancer (CPTAC), 2: Metastatic Breast Cancer (INSERM), 3: The Metastatic Breast Cancer Project, 4: Breast Cancer (METABRIC), 5: Breast Invasive Carcinoma (TCGA, PanCancer Atlas), 6: Breast Invasive Carcinoma (TCGA, Firehose Legacy), 7: Breast Invasive Carcinoma (TCGA), 8: Breast Invasive Carcinoma (TCGA). (B) Specific alterations that are identified in HUNK (each dot represents a single mutation, blue dot = missense mutation, orange dot = nonsense mutation). (C) Kaplan–Meier analysis showing patients with alterations in HUNK have poorer outcomes indicated by median time of overall survival, and (D) relapse free survival shown.