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. 2022 Nov 29;11(12):1731. doi: 10.3390/biology11121731

Table 1.

Senescent cells present in acute cutaneous wounds listed alongside how they contribute to tissue repair.

Senescent Cell Type Role in Healing Process Reference
Fibroblasts Secrete PDGF-AA * in SASP * which helps differentiation of non-senescent fibroblasts [54]
Myofibroblasts Limiting fibrosis through ECM *-degrading-SASP * [55]
Endothelial Promote wound closure through secretion of PDGF-AA * in SASP * [18,54]
Macrophages Inflammation response, debris resolution, tissue remodeling [42]

* Platelet-derived growth factor alpha polypeptide a (PDGF-AA); Senescence-associated secretory phenotype (SASP); Extracellular Matrix (ECM).