Table 1.
Senescent Cell Type | Role in Healing Process | Reference |
---|---|---|
Fibroblasts | Secrete PDGF-AA * in SASP * which helps differentiation of non-senescent fibroblasts | [54] |
Myofibroblasts | Limiting fibrosis through ECM *-degrading-SASP * | [55] |
Endothelial | Promote wound closure through secretion of PDGF-AA * in SASP * | [18,54] |
Macrophages | Inflammation response, debris resolution, tissue remodeling | [42] |
* Platelet-derived growth factor alpha polypeptide a (PDGF-AA); Senescence-associated secretory phenotype (SASP); Extracellular Matrix (ECM).