| amount of drug released at time t | |
| initial amount of drug in the solution (usually ) | |
| total amount of drug released (≈total amount in the dosage system) | |
| drug concentration at time t | |
| initial drug concentration | |
| total drug concentration | |
| saturation concentration (solubility) of drug at given temperature | |
| initial amount of drug encapsulated in the DDS | |
| drug solubility in the matrix | |
| initial amount of drug encapsulated in the DDS | |
| amount of drug remaining in the DDS at time t | |
| percentage release at time t | |
| maximum dissolution | |
| surface area of the DDS | |
| D | diffusion coefficient |
| constant related to surface, shape, and density of particles | |
| number of particles | |
| thickness of the diffusion layer | |
| radius of a spherical matrix | |
| half thickness of the system | |
| timescale parameter | |
| shape parameter (release curve in Weibull, dissolution rate in Gompertz, and nanoparticles shape in Hopfenberg) | |
| equivalence of undissolved proportion at time t = 1 | |
| erosion rate constant | |
| model release constants 1 | |
1 |