Table 1.

Schedule of enrollment, interventions and assessment.

	Screening	Intervention			Outcomes	Extended Intervention		Outcomes
		Baseline
Visit	V1	V2	V3~V6	V7~V11	V12	V13~V17	V18~V22	V23
ENROLLMENT
Informed consent	V					V
Eligibility screen	V	V
Randomized allocation		V
INTERVENTIONS
Opt-tDCS Conv-tDCS Sham-tDCS		V	V	V		V	V
ASSESSMENTS
Baseline variables Vital signs Physical examination MRI scan MEPs EEG Functional examinations		V
Outcome variables MRI scan MEPs EEG Functional examinations		V			V			V
Other variables Adverse events		V	V	V	V	V	V	V