Table 1.

Effects of curcumin on platelets.

S.No.	Parameter	Effect/Mechanism	References
1	Coagulation	Inhibit coagulation, ↓ TNF	[106]
2	Platelet aggregation	Inhibit platelet aggregation and platetlet plug formation, ↓ cell adhesion molecule 1, netrin G1, delta-like 1, and plasma cell endoplasmic reticulum protein-1	[107]
3	Platelets activation	Inhibit activation of platelets to form thrombosis/embolism, ↓ P-selectin, E-selectin, and GP IIb/IIIa	[108]
4	Autophagy	inhibition of PKB, and activation of AMP kinase	[109]
5	Antioxidant effect	↑ antioxidant enzymes, ↓ oxidative stress parameters, ↑ platelet factor-3-like activity	[110,111]
6	Platelet count	↑ platelets level	[112]
7	PDGF	Ameliorated lung fibrosis, liver fibrosis, and cirrhosis, Inhibit PDGF	[113]
8	Platelet aggregation and hyperlipidemia	↓ cholesterol, ↑ antioxidant activity	[114]
9	Atherosclerosis	Thromboxane inhibition, ↑ prostacyclin activity	[115]
10	Arachidonic acid-mediated platelet aggregation	Inhibition of TXA2 and mobilization of intracellular Ca2+	[116]