Table 1.
Comparison of cognitive decline and cognitively stable groups.
| Total | Cognitive Decline | Cognitively Stable | t, Z, or χ2 | p | |
|---|---|---|---|---|---|
| n = 1173 | n = 205 | n = 968 | |||
| Age, years M (IQR) | 54.0 (15.0) | 56.0 (15.0) | 54.0 (14.0) | 2.94 | 0.003 |
| Male (n, %) | 477 (40.7) | 75.0 (36.6) | 402 (41.5) | 1.71 | 0.191 |
| Education, years M (IQR) | 8.0 (4.0) | 7.0 (5.0) | 8.0 (4.0) | 3.46 | 0.001 |
| Smoking (n, %) | 331 (28.2) | 56 (27.3) | 275 (28.4) | 0.10 | 0.752 |
| Drinking (n, %) | 163 (13.9) | 27 (13.2) | 136 (14.0) | 0.11 | 0.741 |
| Lack of exercise (n, %) | 194 (16.5) | 31 (15.1) | 163 (16.8) | 0.36 | 0.548 |
| Dyslipidemia (n, %) | 602 (51.3) | 113 (55.1) | 489 (50.5) | 1.44 | 0.231 |
| Diabetes (n, %) | 142 (12.1) | 30 (14.6) | 112 (11.6) | 1.49 | 0.222 |
| Hypertension (n, %) | 587 (50.0) | 108 (52.7) | 479 (48.5) | 0.69 | 0.405 |
| Cardiovascular disease (n, %) | 68 (5.8) | 14 (6.8) | 54 (5.6) | 0.49 | 0.486 |
| Pulse rate, bpm M (IQR) | 75.0 (10.0) | 75.0 (10.0) | 76.0 (10) | 0.40 | 0.688 |
| BMI, kg/m2 ± SD | 25.4 ± 3.1 | 25.5 ± 3.0 | 25.4 ± 3.2 | 0.39 | 0.697 |
| APOEε4 carriers (n, %) | 181 (15.4) | 28 (13.7) | 153 (15.8) | 0.60 | 0.439 |
| SBP, mmHg ± SD | 131.6 ± 17.7 | 133.5 ± 18.3 | 131.2 ± 17.6 | 1.65 | 0.099 |
| DBP, mmHg ± SD | 82.2 ± 10.7 | 82.2 ± 10.6 | 82.2 ± 10.9 | 0.04 | 0.965 |
| MAP, mmHg ± SD | 98.7 ± 12.1 | 99.3 ± 11.9 | 98.5 ± 12.2 | 0.83 | 0.407 |
| TG, mmol/L M (IQR) | 1.5 (1.0) | 1.5 (1.0) | 1.4 (1.0) | 1.04 | 0.297 |
| TC, mmol/L M (IQR) | 5.0 (1.2) | 5.1 (1.3) | 4.9 (1.2) | 1.05 | 0.315 |
| HDL, mmol/L M (IQR) | 1.35 (0.4) | 1.4 ± (0.4) | 1.4 (0.4) | 0.30 | 0.764 |
| LDL, mmol/L M (IQR) | 3.2 (1.1) | 3.3 (1.2) | 3.2 (1.1) | 0.92 | 0.357 |
| FBG, mmol/L M (IQR) | 5.4 (0.8) | 5.4 (0.8) | 5.4 (0.8) | 0.65 | 0.516 |
| MMSE, M (IQR) | 27 (4) | 28 (4) | 27 (3) | 4.136 | <0.001 |
Abbreviations: M (IQR), median (interquartile range); BMI, body mass index; APOE, apolipoprotein E; SBP, systolic blood pressure; DBP, diastolic blood pressure; MAP, mean arterial pressure; PP, pulse pressure; TG, triglycerides; TC, total cholesterol; HDL, high-density lipoprotein; LDL, low-density lipoprotein; FBG, fasting blood glucose; MMSE, The Mini-Mental State Examination.