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. 2022 Nov 30;11(12):1745. doi: 10.3390/biology11121745

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(A) Comparison of the expression levels of Had1 and Acox3mRNA in w¹¹¹⁸, Hand > w^1118, and Hand > mtp^RNAi hearts under different treatments using one-way ANOVA with LSD for post hoc testing. Compared to the NFD groups, Had1 expression was decreased in HFD + w¹¹¹⁸ and HFD + Hand > w¹¹¹⁸ Drosophila cardiomyocytes, while Acox3 expression was decreased in HFD + w¹¹¹⁸, HFD + Hand > w¹¹¹⁸ and HFD + Hand > mtp^RNAi Drosophila cardiomyocytes. Compared with the HFD groups, there was a general increase in Had1 and Acox3 in w¹¹¹⁸, Hand > w^1118, and Hand > mtp^RNAi Drosophila cardiomyocytes after exercise training. All samples were virgin flies of 10 days (N = 50 per group). (B) Putative role of mtp in β-oxidation in the heart stimulated by exercise training.