Table 1.
DNA methylation age Pearson correlations between blood and airway epithelium.
| DNA Methylation Clock | Group | R between Epigenetic Age and Chronological Age (p-Value) |
R between Blood and Airway Epigenetic Age (p-Value) | COPD Test * (Estimate ± and p-Value) |
||
|---|---|---|---|---|---|---|
| Blood | Airway | Blood | Airway | |||
| DNAmGrimAge | All | 0.83 (1.62 × 10−11) |
0.90 (3.86 × 10−16) |
0.93 (9.86 × 10−19) |
2.86 (2.24 × 10−2) |
2.81 (3.01 × 10−3) |
| COPD | 0.85 (5.05 × 10−5) |
0.93 (6.19 × 10−7) |
0.91 (2.87 × 10−6) |
|||
| Non-COPD | 0.83 (1.04 × 1008) |
0.91 (5.15 × 10−11) |
0.92 (9.80 × 10−12) |
|||
| DNAmAge | All | 0.86 (3.73 × 10−13) |
0.71 (1.35 × 10−7) |
0.59 (4.46 × 10−05) |
1.05 (0.485) |
2.37 (5.12 × 10−2) |
| COPD | 0.85 (5.06 × 10−5) |
0.47 (7.42 × 10−2) |
0.25 (0.360) |
|||
| Non-COPD | 0.85 (1.45 × 10−8) |
0.79 (9.11 × 10−7) |
0.67 (1.34 × 10−4) |
|||
| DNAmAgeHannum | All | 0.87 (4.81 × 10−14) |
0.55 (1.56 × 10−4) |
0.63 (8.75 × 10−6) |
1.46 (0.301) |
4.66 (0.011) |
| COPD | 0.89 (1.06 × 10−5) |
0.70 (3.86 × 10−3) |
0.58 (2.29 × 10−2) |
|||
| Non-COPD | 0.88 (1.95 × 10−9) |
0.50 (8.38 × 10−3) |
0.61 (8.08 × 10−4) |
|||
| DNAmAgeSkinBlood | All | 0.90 (1.06 × 10−15) |
0.64 (4.09 × 10−6) |
0.58 (5.89 × 10−5) |
0.43 (0.767) |
5.03 (2.92 × 10−2) |
| COPD | 0.82 (1.74 × 10−4) |
0.47 (7.83 × 10−2) |
0.13 (0.632) |
|||
| Non-COPD | 0.91 (2.43 × 10−11) |
0.70 (4.82 × 10−5) |
0.69 (7.92 × 10−5) |
|||
| DNAmPhenoAge + | All | 0.79 (5.74 × 10−10) |
0.46 (1.98 × 10−3) |
0.50 (7.80 × 10−4) |
3.13 (0.107) |
5.22 (3.13 × 10−2) |
| COPD | 0.78 (6.54 × 10−4) |
0.44 (9.82 × 10−2) |
0.15 (0.597) |
|||
| Non-COPD | 0.80 4.74 × 10−7) |
0.44 (2.06 × 10−2) |
0.58 (1.68 × 10−3) |
|||
| DNAmTL | All | −0.66 (1.62 × 10−6) |
−0.23 (0.13) |
0.40 (8.72 × 10−3) |
0.05 (0.256) |
−0.23 (4.44 × 10−5) |
| COPD | −0.57 (2.78 × 10−2) |
0.34 (0.200) |
−0.005 (0.986) |
|||
| Non-COPD | −0.72 (1.91 × 10−5) |
−0.32 (0.110) |
0.61 (6.62 × 10−4) |
|||
* Model: epigenetic clock ~ COPD + age, BMI, sex, smoking status; blood analyses were also adjusted for cell proportions, except for DNAmPhenoAge (+ COPD test was not adjusted for cell proportions because these are the main predictors embedded in the DNAmPhenoAge calculation). ± Reference group: non-COPD; positive effects correspond to age acceleration.