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. 2022 Dec 13;10(12):3236. doi: 10.3390/biomedicines10123236

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Immunohistochemical TIGIT expression in OSCC TMA cohort. Representative histopathology (hematoxylin & eosin, H&E) and CD3/TIGIT immunohistochemistry (IHC), respectively, of two cases of oral squamous cell carcinoma (OSCC). (a) (First row) represents an OSCC with stromal and intraepithelial CD3 and TIGIT double-positive T cells (magnification 400X each, 1000X for the inset). (b) (Second row) represents an OSCC with stromal and intraepithelial CD3+ T cells that do not express TIGIT (400X).