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. 2022 Dec 9;10(12):3202. doi: 10.3390/biomedicines10123202

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The BCLC classification system offers treatment recommendations based on tumor stage and liver function of patients with HCC. Treatment options are adjusted to the 5 stages of HCC (from very early to terminal stage). The prognosis is based on the tumor burden, liver function and physical performance status of the patient. Besides the recommended treatments, the BCLC system also includes prognosis and the expected survival time. Updated classifications and treatment options are illustrated as red boxes and arrows. This updated BCLC system further contains new workflows during radiological progression within between the stages (BCLCp-B, BCLCp-C1, BCLCp-C2) [13,14].