Supplementary Table 2.

Trends of tacrolimus trough levels (C₀) during COVID-19 as compared with historical C₀ levels

Current C0 Level (ng/mL)	Current Dose-Adjusted C0 Level	Last Documented Dose-Adjusted C0 Level	Supratherapeutic C0 Level	COVID-19 Associated Rise in Dose--Adjusted C0 Level	Diarrhea During COVID-19	CYP3A5 status
12.6	14.17	9.11	Present	Present	Absent	*3/*3
8.8	16.89	17.6	Present	Absent	Present	*3/*3
8.3	10.79	5.08	Present	Present	Present	*1/*3
24.5	35.9	4.79	Present	Present	Absent	*3/*3
8.52	25.1	23.2	Present	Present	Present	*3/*3
4.19	8.49	19.74	Absent	Absent	Present	*3/*3
7.52	44.33	18.76	Present	Present	Present	*3/*3
4.8	6.66	8.72	Absent	Absent	Present	*1/*3
1.0	2.92		Absent	Absent	Present
7.7	22.9	23.17	Present	Absent	Present
5.2	17.3	19.98	Absent	Absent	Absent	*3/*3
<2	5.6	3.57	Absent	Absent	Absent
6.20	16.12	—	Absent	Absent	Present
16	48	—	Present	Present	Present
<2	7	—	Absent	Absent	Present
16.5	110	22.36	Present	Present	Present	*3/*3
2.91	2.98	3.55	Absent	Absent	Present	*1/*1
>30	98.4	28.8	Present	Present	Present	*3/*3
2.48	6.15	17.18	Absent	Absent	Absent	*1/*3
4.31	7.7	17.8	Absent	Absent	Absent
7.13	33.35	29.2	Present	Present	Present
4.18	9.55	16.7	Absent	Absent	Present
7.84	7.62	4.58	Present	Present	Absent	*1/*1
3.29	4.6	5.07	Absent	Absent	Present	*1/*1
3.2	8.06	10.2	Absent	Absent	Absent
5.4	13.5	11.6	Absent	Absent	Absent
5.92	7.55	8.42	Absent	Absent	Present	*1/*3
6.68	13.36	10	Absent	Absent	Absent	*3/*3
6.48	9.25	9.45	Absent	Absent	Absent
4.82	9.6	—	Absent	Absent	Present	*3/*3
8.4	14.2	—	Present	—	Present
6.1	9.4	—	Absent	—	Present
3.01	4.13	—	Absent	—	Absent
2.87	3.58	—	Absent	—	Present
3.23	6.46	—	Absent	—	Present

COVID-19 - coronavirus disease 2019; CYP3A5 - Cytochrome P450 Family 3 Subfamily A Member 5. *Dose-adjusted C₀ level=level adjusted for 0.1 mg/kg dose=Level (ng/mL) × Current Weight (kg) × 0.1/Dose (mg)