Table 5.
Demographic, clinical, and management parameters that are significantly different in survivors and non-survivors
| Variable | Total (n=60) | Survivors (n=52) | Non-survivors (n=8) | P |
|---|---|---|---|---|
| Baseline characteristics | ||||
| Baseline eGFR (CKD-EPI mL/minute/1.73 m2) | 57.90±20.43 | 60.12±20.10 | 48.38±17.40 | 0.031 |
| Baseline proteinuria (>500 mg/day) | 17 (28.3%) | 11 (21%) | 6 (75%) | 0.015 |
| Historical allograft rejection | 20 (33.3%) | 13 (25.0%) | 7 (87.5%) | 0.001 |
| At admission | ||||
| Dyspnea | 36 (60%) | 28 (53.8%) | 8 (100%) | 0.017 |
| SpO2 | 97 [94-98] | 97.5 [95.25-98] | 88 [79.5-96] | 0.030 |
| Hemoglobin (g/dL) | 11.27±2.39 | 11.60±2.27 | 9.11±2.04 | 0.005 |
| Platelet count (× 109/L) | 1.5 [1.10-2.21] | 1.40 [1.06-1.92] | 0.80 [0.56-0.99] | 0.028 |
| Serum creatinine (mg/dL) | 2.1 [1.4-3.3] | 1.80 [1.4-2.78] | 4.07 [1.77-7.82] | 0.051 |
| SOFA Score Median [IQR] | 3 [1-5] | 3 [1-4] | 6 [5-8] | <0.001 |
| Worst parameters during the course of illness | ||||
| Hemoglobin (g/dL) | 9.91±2.52 | 10.2±2.44 | 7.52±1.68 | 0.003 |
| Platelet count (× 109/L) | 1.35 [1.00-1.70] | 1.40 [1.07-1.87] | 0.70 [0.57-0.95] | 0.001 |
| Blood urea nitrogen (mg/dL) | 31 [22-50.75] | 30 [21-42] | 59 [79-109] | <0.001 |
| Serum creatinine (mg/dL) | 2.40 [1.70-4.70] | 2.30 [1.60-2.90] | 5.90 [4.75-6.25] | 0.001 |
| Serum bicarbonate (mEq/L) | 14 [11.8-18.5] | 16 [12.25-19] | 11 [8.70-13] | 0.005 |
| Aspartate transaminase (U/L) | 37 [24-56] | 28 [23-53] | 61.5 [47.5-493.75] | 0.001 |
| Alanine transaminase (U/L) | 26 [14.5-46.25] | 23.5 [14-31.75] | 76.5 [65.5-291] | <0.001 |
| C-reactive protein (mg/L) | 64.0 [31-105] | 51 [27-81.5] | 234.4 [178-238] | <0.001 |
| Diffuse (>50%) lung involvement on imaging | 22 (36.7%) | 14 (27.5%) | 8 (100%) | <0.001 |
| Inotropes requirement Hypotension | 8 (13.3%) | 1 (1.9%) | 7 (87.5%) | <0.001 |
| Acute graft injury [KDIGO Stage 3] | 17 (28.3%) | 9 (17.35%) | 8 (100%) | <0.001 |
| Hemodialysis | 9 (15%) | 3 (5.88%) | 6 (75%) | <0.001 |
| Presence of severe COVID-19 | 34 (56.4%) | 26 (50%) | 8 (100%) | 0.008 |
eGFR - estimated glomerular filtration rate; CKD-EPI - Chronic Kidney Disease Epidemiology Collaboration; SpO2 - oxygen saturation; COVID-19 - coronavirus disease 2019; KDIGO - kidney diseases improving global outcomes; SOFA - Sequential Organ Failure Assessment; IQR - interquartile range