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. 2022 Nov 30;12(12):1784. doi: 10.3390/biom12121784

Figure 2.

Figure 2

Canonical ECD binding α+/γ− interface, with diazepam (DZ) shown as white sticks bound behind loop C. Other loops implicated in binding or intersubunit interactions are indicated. Cryo-EM map for GABAA(α1)2(β3)2(γ2)1 from PDB 6HUP. Features discussed in the main text are indicated with spheres for residue Cα atoms and dashed lines for cross-linked residue pairs (numbered labels are referenced in the main text). The critical histidine residue in the β4−β5 loop within the BZD binding pocket (i) and the central valine residue in the α1 M2-M3 linker (viii) are shown as sticks.