Table 1.

Potential targets and therapeutic effect of CBD in dementias.

Receptors	Action	Pharmacology Propriety
CB1	Direct antagonist and negative allosteric modulation antagonist	Attenuation of learning deficit, memory, and psychotic effects of THC
CB2	Antagonist & reverse agonist	Anti-inflammatory
GPR55	Antagonist	Antitumor
5HT1A	Agonist	Analgesia and anxiolytic
mAChR	Agonist	Cognition improvement
TRPV1	Agonist	Anti-inflammatory and analgesia
PPARγ	Agonist	Antioxidant and anti-inflammatory

Legend: CB1 Cannabinoid receptor type 1; CB2, cannabinoid receptor type 2; GPR55, G-protein-coupled receptor 55; 5HT1A Serotonin 1A receptor; mAChR, muscarinic acetylcholine receptor; TRPV1, transient receptor potential vanilloid type 1; PPARγ, peroxisome proliferator-activated receptor gamma.