Table 1.
Study characteristics.
| Topic | Author, Reference | Os Marker | Cytoprotective Mechanism | Cellular Damage Mechanism |
|---|---|---|---|---|
| UVA1 | Bernerd et al. [31] | NRF2 | Upregulation of NRF2 target genes: HMOX1, TXNRD1, NQO1, FTL, GCLM, AKR1C2, AKR1C3 | // |
| PDT | Broekgaarden et al. [32] | NRF2 | Activation of JNK and NRF2-KEAP1 dissociation. Activation of ARE sequences by NRF2-AP1 and transcription of NRF2 target genes. Upregulation of HMOX1 HIF-1-mediated genes. | // |
| UVB | Ryšavá et al. [33] | NRF2 | // | Direct DNA damage and downregulation of NRF2 target genes |
| UVB | Vieyra-Garcia et al. [34] | // | // | NLRP3 inflammasome activation |