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. 2022 Dec 9;14(24):6062. doi: 10.3390/cancers14246062

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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GPC3 is elevated in HBL patients by β-catenin-TCF4-p300 pathway via CEGRs/ALCDs in GPC3 gene. (A) Structure of the GPC3 gene. The 100% homologous TCF4 binding site is shown in the blue box. (B) ChIP assay with the third CEGR/ALCD of GPC3. (C) GPC3 mRNA expression in a fresh biobank of HBL samples (n = 32) (p = 0.3202, unpaired t-test). (D,E) IF staining of pediatric liver cancer sections with antibodies to GPC3. (F) GPC3 expression in specimens from a fresh biobank was determined by Western blot. (G) Levels of GPC3 in blood of eight HBL patients with active ph-S675-β-catenin-TCF4-CEGRs/ALCDs-GPC3 pathway in liver tumors. The uncropped Western blots have been shown in Figure S9.