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. 2022 Nov 28;10(12):3061. doi: 10.3390/biomedicines10123061

Table 3.

Transcriptional factors and non-coding RNAs contributing to CYP3A expression in the liver and the small intestine.

Liver (n = 193)
Dependent Variable Independent Variable Type R-Square p-Value R-Square Change Beta p-Value
CYP3A4 68.11% 3.19 × 10−36
ESR1 humanTF 36.36% 0.488 1.44 × 10−9
DBH-AS1 lncRNA 0.80% −0.462 1.23 × 10−6
AL161668.4 lncRNA 2.17% −0.411 3.74 × 10−6
AC008537.3 lncRNA 1.94% 0.334 3.88 × 10−6
HNF4A-AS1 lncRNA 2.60% 0.515 5.18 × 10−6
AC027682.6 lncRNA 2.48% −0.346 1.29 × 10−4
HIF1A humanTF 0.86% −0.262 1.84 × 10−3
AC004160.2 lncRNA 3.95% 0.186 2.75 × 10−3
LINC02499 lncRNA 2.59% −0.266 6.23 × 10−3
CTD-2325A15.5 lncRNA 1.46% −0.172 1.12 × 10−2
AC122713.2 lncRNA 0.94% −0.179 1.13 × 10−2
ZNF385B humanTF 0.79% 0.234 1.82 × 10−2
AL359715.3 lncRNA 0.84% 0.146 2.11 × 10−2
HMGB3 humanTF 0.82% −0.159 3.40 × 10−2
ZGPAT humanTF 0.73% 0.221 3.53 × 10−2
CYP3A5 69.52% 2.10 × 10−39
LINC02499 lncRNA 48.48% 0.514 3.84 × 10−8
AL161668.4 lncRNA 1.50% −0.407 9.04 × 10−7
HLF humanTF 2.48% 0.302 2.16 × 10−4
CTD-2325A15.5 lncRNA 1.77% −0.242 2.49 × 10−4
AL122035.2 lncRNA 0.71% 0.211 9.84 × 10−4
HMGB3 humanTF 1.19% −0.214 2.67 × 10−3
ZNF680 humanTF 0.86% −0.203 3.44 × 10−3
NFYC humanTF 0.74% 0.174 8.33 × 10−3
AC008537.3 lncRNA 0.99% 0.179 1.11 × 10−2
NR1I2 humanTF 0.41% 0.187 1.86 × 10−2
GCFC2 humanTF 2.01% 0.157 2.45 × 10−2
ZNF473 humanTF 0.62% 0.146 2.48 × 10−2
AC137056.1 lncRNA 0.47% −0.142 3.26 × 10−2
CYP3A7 44.52% 1.64 × 10−19
HNF4A-AS1 lncRNA 23.84% 0.875 1.84 × 10−8
DCXR-DT lncRNA 4.53% −0.447 3.24 × 10−5
AL161668.4 lncRNA 2.32% −0.431 8.09 × 10−5
AL117382.3 lncRNA 1.52% −0.267 1.83 × 10−2
AL513327.1 lncRNA 1.98% −0.169 2.49 × 10−2
AC104809.1 lncRNA 1.48% 0.193 2.88 × 10−2
AC083841.1 lncRNA 1.44% 0.186 3.04 × 10−2
NR3C2 humanTF 2.48% 0.154 7.77 × 10−2
RP11-669E14.4 lncRNA 4.94% 0.151 9.43 × 10−2
Small Intestine (n = 175)
Dependent Variable Independent Variable Type R-Square p-Value R-Square change Beta p-Value
CYP3A4 95.67% 3.18 × 10−101
NR1I2 humanTF 1.46% 0.937 1.05 × 10−13
CREB3L3 humanTF 2.34% 0.427 1.28 × 10−8
LOC102724153 lncRNA 83.59% 0.362 5.84 × 10−7
FOXA3 humanTF 1.52% −0.323 1.23 × 10−5
BARX2 humanTF 0.91% −0.293 2.24 × 10−5
CTD-2547H18.1 lncRNA 0.63% 0.207 1.03 × 10−4
GATA6 humanTF 0.19% 0.186 1.49 × 10−4
LINC02323 lncRNA 3.60% −0.198 1.95 × 10−4
OVOL2 humanTF 0.21% −0.298 3.63 × 10−4
RP11-284F21.10 lncRNA 0.20% −0.214 1.93 × 10−3
SPINT1-AS1 lncRNA 0.17% 0.209 3.36 × 10−3
LINC02313 lncRNA 0.28% 0.121 4.17 × 10−3
LOC105375431 lncRNA 0.43% −0.123 1.60 × 10−2
MNX1-AS2 lncRNA 0.15% −0.116 1.93 × 10−2
CYP3A5 98.09% 7.01 × 10−127
NR1I2 humanTF 0.64% 0.771 2.67 × 10−22
RP11-63P12.7 lncRNA 1.64% 0.255 4.15 × 10−11
MLXIPL humanTF 0.55% 0.132 1.13 × 10−9
HNF1B humanTF 0.28% 0.409 4.42 × 10−9
RP3-523K23.2 lncRNA 0.15% −0.264 1.94 × 10−6
ZBTB7B humanTF 0.20% −0.190 1.25 × 10−5
KBTBD11-OT1 lncRNA 0.14% −0.137 1.29 × 10−5
RP11-150O12.3 lncRNA 0.25% −0.143 1.07 × 10−4
RP11-284F21.9 lncRNA 0.30% 0.127 7.77 × 10−4
TBILA lncRNA 0.12% 0.121 1.46 × 10−3
TBX10 humanTF 0.38% −0.107 3.69 × 10−3
RP11-284F21.10 lncRNA 0.08% −0.138 7.97 × 10−3
LINC00543 lncRNA 0.35% −0.093 8.63 × 10−3
MNX1 humanTF 0.08% 0.122 1.33 × 10−2
RP13-497K6.1 lncRNA 0.11% 0.050 1.52 × 10−2
LOC100128770 lncRNA 0.05% 0.074 4.77 × 10−2
CYP3A7 80.38% 4.53 × 10−50
RP11-94C24.13 lncRNA 6.16% 0.470 5.77 × 10−9
FOXD1 humanTF 2.04% −0.347 3.14 × 10−7
NR6A1 humanTF 0.91% 0.367 2.38 × 10−4
NR3C2 humanTF 2.01% 0.307 2.40 × 10−4
ONECUT3 humanTF 0.77% −0.209 8.86 × 10−4
RP11-503C24.6 lncRNA 62.50% 0.345 9.47 × 10−4
RP11-794G24.1 lncRNA 1.78% −0.234 1.50 × 10−3
ZNF664 humanTF 0.82% −0.225 1.94 × 10−3
RP11-459I19.1 lncRNA 0.76% −0.212 2.21 × 10−3
EGFR-AS1 lncRNA 0.60% 0.310 5.12 × 10−3
LOC105373958 lncRNA 0.65% 0.180 5.81 × 10−3
RAG1 humanTF 0.69% 0.190 1.04 × 10−2
RP11-211N11.5 lncRNA 0.70% −0.164 1.78 × 10−2

Βeta: standardized coefficients.