Table 2.
Correlation analyses between intra-tumoral S-TLSs and the patients’ clinicopathological characteristics.
| Clinicopathological Variables |
S-TLS− pCCA n = 32 (34.4%) |
S-TLS+ pCCA n = 61 (65.6%) |
p-Value |
|---|---|---|---|
| Age, years | |||
| ≤60 | 24 | 30 | 0.017 |
| >60 | 8 | 31 | |
| Sex | |||
| male | 14 | 39 | 0.062 |
| female | 18 | 22 | |
| Tumor size, cm | |||
| ≤2.5 | 6 | 21 | 0.114 |
| >2.5 | 26 | 40 | |
| Differentiation | |||
| moderate + good | 24 | 49 | 0.552 |
| poor | 8 | 12 | |
| T stage | |||
| T1 + T2 | 17 | 45 | 0.045 |
| T3 + T4 | 15 | 16 | |
| Lymph node metastasis | |||
| absence | 12 | 42 | 0.004 |
| presence | 20 | 19 | |
| M stage | |||
| M0 | 31 | 57 | 0.657 * |
| M1 | 1 | 4 | |
| TNM stage | |||
| I + II | 8 | 31 | 0.017 |
| III + IV | 24 | 30 | |
| CEA, ng/mL | |||
| ≤4 | 17 | 36 | 0.586 |
| >4 | 15 | 25 | |
| CA19-9, U/mL | |||
| ≤135 | 8 | 23 | 0.217 |
| >135 | 24 | 38 | |
| HBsAg | |||
| absence | 25 | 50 | 0.656 |
| presence | 7 | 11 | |
| Microscopic residual tumor | |||
| R0 | 24 | 45 | 0.898 |
| R1 | 8 | 16 |
S-TLS, secondary follicle-like TLS; TLS, tertiary lymphoid structure; CEA, carcinoembryonic antigen; CA19-9, carbohydrate antigen 19-9. * Fisher’s exact test was used, others Chi-squared test.