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. 2022 Dec 17;10(12):3279. doi: 10.3390/biomedicines10123279

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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L1 could act as ceRNA when artificially overexpressed. (A). TE subfamilies significantly deregulated in the ORFeus-OE model. In this experiment, the L1 construct is the most upregulated TE with a log2 fold-change of 10.92. (B). Analysis to detect autonomous transcription of L1. In ORFeus-OE cells, the upregulation of L1 is deriving from an autonomous transcription of the ORFeus element. (C). Analysis of miRNA target sites sharing between artificial L1 construct and the 3′UTRs of protein-coding genes in ORFeus-OE model. The upregulated genes share a significantly high number of miRNA target sites with the L1 construct, reflecting a possible ceRNA activity of the artificial construct transcript.