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Effect of blockade of B7-1 or B7-2 on intra-abdominal abscess formation by B. fragilisb
| Treatmenta | No. of animals positive for abscesses/total (%) | Pc |
|---|---|---|
| Saline | 17/20 (85) | |
| Y100FIg (binds to B7-1) | 9/10 (90) | NSd |
| L6Ig | 7/10 (70) | NS |
| Anti-B7-2 | 0/7 (0) | 0.0001 |
| IgG control | 5/5 (100) | NS |
Fusion protein (500 μg/ml) was administered via the intracardiac route.
Animals were challenged with B. fragilis at 108 CFU/rat.
Compared to the saline control.
NS, not significant.
