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CAR-T, CAR-NK and CAR-M signalling domains. Main domains applied in CAR constructions.
| CAR-T | CAR-NK | CAR-M |
|---|---|---|
| CD3ζ | CD3ζ | CD3ζ |
| CD3γ | CD28 | CD28 |
| CD28 | 4−1ΒΒ | 4−1ΒΒ |
| 4−1ΒΒ | CD137 | Megf10 |
| OX40 | 2B4 | MerTK |
| CD20 | DAP10 | PI3K |
| CD137 | DAP12 | CD86 |
| ICOS | NKG2D | CD147 |
| CD40 | CD244 | TLR2 |
| CD27 | Etc. | TLR4 |
| Etc. | TLR6 |
