Table 2.

Processes connected to coagulation in the lungs of COVID-19 patients.

Coagulation
Upregulation	Downregulation	SARS-CoV-2 Infection Effects
Von Willebrand factor, ICAM-1, VCAM-1	-	Platelets activation Clotting initiation Increased risk of thrombosis
TIMP1, MMP2, MMP11, VWF	-	Impacted coagulation processes - Platelet adhesion Development of inflammation
CD62P (P-selectin) TF (tissue factor)	-	Excessive platelet activation Initiation of the extrinsic coagulation cascade Induction of hypercoagulability
PABPC4, VKORC1	ADAMTS13	Induction of hypercoagulability
TLR3, TLR4, TLR7, TLR8	-	Induction of hypercoagulability Initiation of the extrinsic coagulation cascade
MASP1, MASP2	-	Activation of the classical and lectin complement pathways Catalytic role against prothrombin and fibrinogen
SERPINE1	-	Inhibition of the fibrinolysis process
PLAT PLG FGB	uPA uPAR	Local fibrinolysis reduction and pulmonary thrombosis predisposition D-dimer production
-	THBD, PROS1	Development of thrombotic complications