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Processes in the COVID-19 lungs involved in fibrosis formation.
| Fibrosis | ||
|---|---|---|
| Upregulation | Downregulation | SARS-CoV-2 Infection Effects |
| TGF | ACE2/Ang- (1-7)/MasR axis | Inflammation and fibrosis promotion |
| Th1 cells, GM, CSF, IL-6, IL-10, IL 1, IL-1, TNF | - | Cytokine storm induction Remodeling of the lung tissue/fibrosis |
| KL-6 antigen | - | Pulmonary fibrosis promotion |
| MMP9, MMP7 | MMP2 | Pulmonary fibrosis promotion |
| YKL-40 | - | Important role in the tissue remodeling |
