Table 2.
Comparison of SERS and LSPR-based nanobiosensors for viral DNA detection.
| Analytical Method | Feature | Target | Required Time | Detection Limit | Ref |
|---|---|---|---|---|---|
| Raman | Raman spectroscopy combined with the airPLS-PCA-PSOSVM model | HBV DNA | - | - | [58] |
| SERS | Raman-sensitive system composed of ssDNA-immobilized Raman probe-functionalized Au nanoparticles (RAuNPs) on the graphene oxide (GO)/triangle Aunanoflower array. | HBV, HPV-16, HPV-18 DNA | 20 min | 1 aM | [59] |
| SERS | AuNPs aggregation-based surface-enhanced Raman scattering (CRISPR/Cas-SERS) platform | HPV DNA | 40 min | 6.72 pM | [60] |
| SERS | Au−Os−CO−Au Functionalized SERS-Active Substrate | Epstein-Barr Virus DNA | 30 min | 600 copies/mL | [61] |
| SERS | Hierarchic-nanocube-assembly based SERS (H-Cube-SERS) bioassay to controllably amplify the electromagnetic field between gold nanocubes | HAV DNA | 30 min | 100 aM | [62] |
| LSPR | Plasmonic CRISPR Cas12a-based assay using DNA-functionalized AuNP |
Red-Blotch Viral DNA | 15 min | 200 pM | [67] |
| LSPR | Plasmonic gold nanoparticles for ratiometric genosensing of Hepatitis C virus using citrate buffer and flash heating in enhancing the sensitivity | HCV DNA | 20 min | - | [68] |