Electrochemical aptasensors based on gold electrode platforms for E2 detection. The gold-based aptasensor electrode platforms are the (A) gold/streptavidin/biotin–aptamer electrode. Reprinted with permission from Ref. [35] copyright © 2022, Elsevier, (B) gold/PEDOT/AuNPs/streptavidin/biotin–aptamer electrode. Reprinted with permission from Ref. [47] copyright © 2022, MDPI, (C) gold–aptamer electrode. Reprinted with permission from Ref. [38] copyright © 2022, The Royal Society of Chemistry, (D) dendritic gold/BDD electrode. Reprinted with permission from Ref. [37] copyright © 2022, Elsevier, (E) gold/nickel hexacyanoferrate/Au NPs electrode. Reprinted with permission from Ref. [48] copyright © 2022, Elsevier, (F) gold-split aptamer electrode. Reprinted with permission from Ref. [49] copyright © 2022, Elsevier. The gold–thiol bond aptamer immobilization strategy was implemented for gold-based electrodes.