Figure 1.

Associations and restricted cubic splines of plasma levels of AGEs-RAGE axis with risk of breast cancer. (A) Associations of plasma levels of AGEs-RAGE axis with risk of breast cancer. Restricted cubic splines of plasma levels of AGEs (B), RAGE (C), and AGEs/sRAGE-ratio (D) with risk of breast cancer. Covariates: body mass index, education, menarche age, menopause, estrogen replacement therapy, smoking, drinking, negative events, history of benign breast disease, breast cancer history of first-degree relatives. Abbreviations: AGEs, advanced glycation end-products; CI, confidence interval; OR, odds ratio; SD, standard deviation; sRAGE, soluble receptor for advanced glycation end-products.