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Isoform-specific uncoupler. Concentration response curve of compound #12 (DS60405307) shows an inhibition of Ca2+ uptake activity despite a substantial increase in ATPase activity in cardiac SR. However, the same compound has a small but significant increase in Ca2+ uptake activity in skeletal SR. This tissue-dependent effect is presumably due to SERCA2a (cardiac) vs. SERCA1a (skeletal) isoform differences or the presence/absence of regulators (PLB vs. SLN). n = 3, ± SEM.
