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. 2022 Nov 27;44(12):5902–5914. doi: 10.3390/cimb44120402

Figure 7.

Figure 7

The suppressive effects of LY294002 on the neuroprotective action of Arecae Pericarpium ethanol extract. HT22 cells were incubated with or without APE combined with LY294002 before glutamate treatment. (A) Cell viability and, (B) Activation of protein kinase B, Nrf-2, and HO1 were assessed using a cell-counting kit assay and Western blot analysis, respectively. Control was non-treated cells. Blot images represent the three independent experiments. Data were presented as mean ± standard error of the mean. Statistical significance was set at # p < 0.05 (vs. control), † p < 0.001 (vs. glutamate), and *** p < 0.001 (vs. APE). Akt, protein kinase B; APE, Arecae Pericarpium ethanol extract; Con, control; Glu, glutamate; HO, heme oxygenase; LY, LY294002; Nrf-2, nuclear factor erythroid 2-related factor 2.