Table 2.
Variable | Odds Ratio ” | 95% CI | p |
---|---|---|---|
Treatment prior to allo-SCT Upfront #/CR vs. No CR |
3.402 | 1.140–10.155 | 0.028 |
ELN 2017//IPSS-R//CPSS at diagnosis (14,16,18) * Favorable/intermediate Unfavorable |
2.777 | 0.755–10.213 | 0.124 |
Karyotype Not complex vs. Complex |
3.038 | 0.695–13.278 | 0.140 |
” Odds ratio represents odds of late relapse versus odds of early relapse among patients who experienced relapse. # upfront: patients who proceeded to transplantation without prior cytoreductive chemotherapy, defined as no MDS- or AML-MRC-specific therapy except for growth factors, transfusions and a short period (<1 week) of hydroxyurea. * very good/good IPSS-R, favorable ELN and low CPSS risk groups were combined as one favorable disease risk group; intermediate IPSS-R, intermediate ELN and intermediate I/II CPSS formed one intermediate disease risk group; and high/very high IPSS-R, adverse ELN and high CPSS were summarized as one unfavorable disease risk group. The disease risk of patients with MDS, AML-MRC and CMML was estimated using IPSS-R, ELN 2017 classification and CPSS, respectively, and the respective subgroups were summarized as described above. Allo-SCT, allogeneic hematopoietic stem-cell transplantation; CI, confidence interval; CPSS, CMML-specific scoring system; CR, complete Remission; int, intermediate; ELN, European Leukemia Net; IPSS-R, International Prognostic Scoring System—Revised Version.