Table 5.
Patients with the CFTR gain-of-function complex allele [G576V;R668C].
| Female | Male | ||||
|---|---|---|---|---|---|
| Total | Age < 50 y (n = 289) |
Age ≥ 50 y (n = 765) |
Age < 50 y (n = 317) |
Age ≥ 50 y (n = 1214) |
|
| Individuals | 41 | 3 (1.04) | 11 (1.44) | 4 (1.26) | 23 (1.89) |
| COVID Outcome Scale, No. (%) | |||||
| Cat. 1 (Death; n = 164) | 1 (0.61) | 0 | 1 (1.47) | 0 | 0 |
| Cat. 2 (Invasive mechanical ventilation; n = 180) | 2 (1.11) | 0 | 1 (2.78) | 0 | 1 (0.87) |
| Cat. 3 (CPAP/BiPAP; n = 584) | 15 (2.57) | 0 | 6 (3.68) ° | 1 (1.82) | 8 (2.34) |
| Cat. 4 (Hospitalized, receiving supplemental low-flow oxygen; n = 850) | 11 (1.29) | 0 | 2 (0.69) | 1 (1.27) | 8 (1.81) |
| Cat. 5 (Hospitalized, not receiving supplemental oxygen; n = 347) | 4 (1.15) | 1 (1.72) | 1 (1.04) | 0 | 2 (1.54) |
| Cat. 6 (Not hospitalized; n = 460) | 8 (1.74) | 2 (1.23) | 0 | 2 (2.08) | 4 (4.4) * |
° p < 0.05 vs. category 4 same age and sex with Fisher exact. * p = 0.06 vs. category 1 same age and sex with Fisher exact. The percentage reported in the first column refers to the number of patients in the corresponding clinical category. The one reported in the other columns refers to the group of patients with their age and sex reported in the corresponding column and their clinical category in the related raw data.