Table 6.
Patients with CFTR ultra-rare alleles with reduced residual activity.
| Female | Male | ||||
|---|---|---|---|---|---|
| Total (n = 2585) | Age < 50 y (n = 289) |
Age ≥ 50 y (n = 765) |
Age < 50 y (n = 317) |
Age ≥ 50 y (n = 1214) |
|
| Individuals | 114 | (n = 13) | (n = 25) | (n = 20) | (n = 56) |
| COVID Outcome Scale, No. (%) | |||||
| Cat. 1 (Death; n = 164) | 13 (7.93) *,° | 0 | 4 (5.88) | 0 | 9 (9.68) * |
| Cat. 2 (Invasive mechanical ventilation; n = 180) | 10 (5.56) | 0 | 3 (8.33) * | 3 (13.04) | 4 (3.48) |
| Cat. 3 (CPAP/BiPAP; n = 584) | 27 (4.62) | 1 (4.17) | 7 (4.29) | 3 (5.45) | 16 (4.68) |
| Cat. 4 (Hospitalized, receiving supplemental low-flow oxygen; n = 850) | 29 (3.41) | 2 (5.41) | 4 (1.37) | 5 (6.33) | 18 (4.06) |
| Cat. 5 (Hospitalized, not receiving supplemental oxygen; n = 347) | 13 (3.75) | 2 (3.45) | 3 (3.12) | 2 (3.17) | 6 (4.62) |
| Cat. 6 (Not hospitalized; n = 460) | 22 (4.78) | 8 (4.94) | 4 (3.6) | 7 (7.29) | 3 (3.30) |
* p < 0.05 vs. category 4. ° p = 0.05 vs. category 5. The percentage reported in the first column refers to the number of patients in the corresponding clinical category. The one reported in the other columns refers to the group of patients with their age and sex reported in the corresponding column and their clinical category in the related raw data.