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. 2022 Dec 14;14(24):6164. doi: 10.3390/cancers14246164

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Loss of PTEN activates NF-κB and inflammatory pathways. (A) A dataset of WT- and PTEN-deficient prostate epithelial cells from a mouse model of prostate cancer [47] was reanalyzed on the NetworkAnalyst platform by comparing differentially expressed genes with the protein interactome of the STRING database and computing a minimal joint network. Upregulated nodes (shown in red) were then queried against the Reactome database to elucidate functional enrichments. Inflammatory pathways were selected, which are highlighted by black borders of the respective nodes. (B) Overview of the most significantly enriched Reactome pathways among upregulated genes. Black frames around the pathway terms are those reflecting the black borders in (A). Negative log-p-values are plotted in such a way that the bubble size represents the gene ratio (regulated genes/total pathway genes) and the color reflects the ratio of gene hits per expected.