Figure 9.

Mathematical simulation of a dynamic network between AR, NF-κB/IκB, and c-Myc. (A) Interdependent network between AR, NF-κB/IκB, PI3K/PTEN, and c-Myc with estimated activating or inhibitory links as indicated by the numbers of lines linking the nodes. The presence of androgens provides a stimulatory effect on AR. (B) Time course of activities (arbitrary units) as predicted by the model. Loss of androgens or inhibition of AR (androgen-ablation arrow) leads to upregulation of NF-κB and c-Myc activities, while subsequent inhibition of NF-κB and PI3K results in a downregulation of c-Myc activity below the original level.