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. 2022 Dec 7;12(12):3079. doi: 10.3390/diagnostics12123079

Table 1.

Overview of representative DT studies. Major results are presented. AUC value was not mentioned in the literature unless described. Digital tomosynthesis: DT; tomosynthesis with metal artifact reduction: TMAR; computed tomography: CT; total hip arthroplasty: THA; anterior cruciate ligament: ACL; interclass correlation coefficient: ICC.

Compared Modalities Subject Results
Tang et al. [21] Radiography,
DT with TMAR,
CT
4 cadaveric femurs
Femoral stem
Sensitivity
  Radiography 20.5%
  DT with TMAR 63.3%
  CT 50.2%
Specificity
  Radiography 92.5%
  DT with TMAR 87.5%
  CT 82.5%
Ottenin et al. [18] Radiography,
DT
CT
100 patients with acute wrist trauma
Carpal bones
Sensitivity
  Radiography 61–80%
  DT 77–87%
  CT 93–95%
Specificity
  Radiography 65–83%
  DT 76–82%
  CT 86–95%
Tang et al. [1] Radiography,
DT with TMAR,
CT
48 patients with cementless THA
(Femoral stem and acetabular cup)
Diagnostic accuracy
Femoral stem
  Radiography 84.5%
  DT with TMAR 82.6%
  CT 44.6%
Acetabular cup
  Radiography 39.6%
  DT with TMAR 67.3%
  CT 74.6%
Guo et al. [22] Radiography,
DT with TMAR,
CT
24 patients with cementless THA

13 femoral stems and 14 acetabular components were evaluated.
Sensitivity
Femoral side
  Radiography 50.4%
  DT with TMAR 73.8%
  CT 36.4%
Acetabular side
  Radiography 45.9%
  DT with TMAR 60.2%
  CT 45.1%

Specificity
Femoral side
  Radiography 87.8%
  DT with TMAR 94.3%
  CT 90.9%
Acetabular side
  Radiography 66.4%
  DT with TMAR 86.4%
  CT 73.5%
Gillet et al. [23] Radiography
DT
CT + MAR
49 patients with painful hip prostheses.
Evaluated prosthestic loosening.
Sensitivity
  Radiography 33.3–51.5%
  DT 39.9–45.4%
  CT + MAR 84.5%
Specificity
  Radiography 96.9–100%
  DT 98.5–100%
  CT + MAR 95.4–96.9%
Toyooka et al. [24] DT
CT
Bone integration of 27 patients who underwent ACL reconstruction was evaluated DT was equivalent to CT for the evaluation of bone plug integration within a 15% diagnostic error.

Sensitivity 79–96%
Specificity 64–100%
Diagnostic accuracy 81–96%
Ishibashi et al. [25] DT Open Wedge High Tibial osteotomy
Gap filling value (GFV)
and modified van Hemert’s score (MVHS)
GFV had strong correlation with MVHS
(r = 0.630, p < 0.001)

ICC value for intraobserver reliability
GFV 0.958
MVHS 0.978

ICC value for interobserver reliability
GFV 0.975
MVHS 0.950
Mataki et al. [27] DT Pedicle screw (PS)
displacement angle
Loosening group vs. group without PS loosening
The displacement angle was significantly greater in loosening group (5.7° vs. 0.6°)

Sensitivity 100%
Specificity 93%
AUC = 0.98