Table 3.
Significant changes in 37 microbial pathways in oral microbiome in nonsmoking OC-SCC patients.
| Class | Pathway | Control * | Cancer * | Fold Change | q Value |
|---|---|---|---|---|---|
| Vitamin | PWY-6519: 8-amino-7-oxononanoate biosynthesis I | 11 | 17 | 1.530 | 0.028 |
| BIOTIN-BIOSYNTHESIS-PWY: biotin biosynthesis I | 12 | 18 | 1.491 | 0.028 | |
| PWY-7539: 6-hydroxymethyl-dihydropterin diphosphate biosynthesis III | 28 | 37 | 1.293 | 0.057 | |
| RIBOSYN2-PWY: flavin biosynthesis I bacteria and plants | 29 | 36 | 1.243 | 0.023 | |
| THISYNARA-PWY: superpathway of thiamin diphosphate biosynthesis III | 29 | 34 | 1.202 | 0.059 | |
| PWY-6168: flavin biosynthesis III | 30 | 35 | 1.194 | 0.059 | |
| PWY-6147: 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I | 65 | 76 | 1.166 | 0.031 | |
| PWY-6897: thiamin salvage II | 39 | 43 | 1.112 | 0.094 | |
| PWY-3841: folate transformations II | 66 | 58 | 0.874 | 0.059 | |
| 1CMET2-PWY: N10-formyl-tetrahydrofolate biosynthesis | 57 | 50 | 0.873 | 0.059 | |
| Heme | HEME-BIOSYNTHESIS-II: heme biosynthesis I aerobic | 23 | 30 | 1.322 | 0.028 |
| PWY-5918: heme biosynthesis from glutamate | 33 | 40 | 1.216 | 0.059 | |
| Nucleotide | PWY-7228: guanosine nucleotides de novo biosynthesis I | 85 | 80 | 0.947 | 0.077 |
| PWY-6126: adenosine nucleotides de novo biosynthesis II | 98 | 92 | 0.946 | 0.098 | |
| PWY-841: purine nucleotides de novo biosynthesis I | 71 | 66 | 0.938 | 0.094 | |
| PWY-6125: guanosine nucleotides de novo biosynthesis II | 81 | 76 | 0.938 | 0.077 | |
| PWY-7208: pyrimidine nucleobases salvage | 79 | 73 | 0.923 | 0.059 | |
| PWY-7197: pyrimidine deoxyribonucleotide phosphorylation | 66 | 61 | 0.920 | 0.077 | |
| PWY-7220: adenosine deoxyribonucleotides de novo biosynthesis II | 72 | 66 | 0.917 | 0.059 | |
| PWY-7222: guanosine deoxyribonucleotides de novo biosynthesis II | 72 | 66 | 0.917 | 0.059 | |
| PWY0-1296: purine ribonucleosides degradation | 67 | 57 | 0.850 | 0.057 | |
| tRNA | TRNA-CHARGING-PWY: tRNA charging | 34 | 39 | 1.152 | 0.059 |
| Amino acid | ILEUSYN-PWY: L-isoleucine biosynthesis I from threonine | 93 | 87 | 0.937 | 0.094 |
| VALSYN-PWY: L-valine biosynthesis | 93 | 87 | 0.937 | 0.094 | |
| PWY-2941: L-lysine biosynthesis II | 59 | 54 | 0.914 | 0.090 | |
| PWY-6936: seleno-amino acid biosynthesis | 76 | 69 | 0.907 | 0.059 | |
| PWY0-781: aspartate superpathway | 35 | 32 | 0.895 | 0.065 | |
| P4-PWY: L-lysine L-threonine and L-methionine biosynthesis I | 42 | 37 | 0.895 | 0.094 | |
| PWY-5347: L-methionine biosynthesis transsulfuration | 52 | 43 | 0.831 | 0.023 | |
| Sugar | DTDPRHAMSYN-PWY: dTDP-L-rhamnose biosynthesis I | 43 | 49 | 1.148 | 0.094 |
| CALVIN-PWY: Calvin-Benson-Bassham cycle | 49 | 55 | 1.120 | 0.038 | |
| Fatty acid | PWY-5973: cis-vaccenate biosynthesis | 54 | 58 | 1.087 | 0.094 |
| Fermentation | ANAEROFRUCAT-PWY: homolactic fermentation | 38 | 41 | 1.096 | 0.059 |
| PWY-7111: pyruvate fermentation to isobutanol engineered | 94 | 87 | 0.932 | 0.077 | |
| PWY-7383: anaerobic energy metabolism invertebrates cytosol | 27 | 22 | 0.849 | 0.059 | |
| Cell wall | PWY0-1586: peptidoglycan maturation | 20 | 17 | 0.848 | 0.063 |
| PWY-6471: peptidoglycan biosynthesis IV Enterococcus faecium | 21 | 16 | 0.742 | 0.028 |
* Reads per 100,000 reads.