TABLE 12.
Clinical trials that studied soy fiber consumption in adults without gastrointestinal disease
| Study | Population | Design | Duration | Dose | Control (vehicle) | Treatment (vehicle) | Assessment | Responses |
|---|---|---|---|---|---|---|---|---|
| Kondo, 1996 (109) | Healthy adults in Japan (n = 5; 3 F, 2 M), 22–48 y | Postprandial | 6-h monitoring, each beverage on separate day | 6 g/d | 10.2 g/d lactulose (soft drink) | Soybean oligosaccharide (Calpis Food Engineering Oligo CC soft drink) | Orocecal transit time, flatulence (no quantitative assessment) | Orocecal transit time was constant across treatments and flatulence was common |
| Schweizer, 1983 (124) | Healthy adults in Switzerland (n = 6; 4 F, 2 M), 24–30 y, 102–110% ideal body weight | Crossover | 2-wk control period, 3 wk/treatment | 21 g/d | None (usual diet) | Nonpurified soy fiber, 39% (yogurt and soups), purified soy fiber, 79% (yogurt, milk, soup, or water) | Stool frequency and weight, transit time | Low and high soy fiber ↑ fecal wet weight by 19% and 38%, respectively, compared with control period.1 |
| Tsai, 1983 (125) | Healthy males in the United States (n = 14), 20–30 y, 73.1 ± 5.3 (control) and 70.6 ± 5.9 (fiber) | Diet controlled, crossover | Two 17 d-feeding periods | 25 g/d | None (low-fiber basal diet) | Soy polysaccharide (low-fiber basal diet) | Transit time, fecal moisture and dry matter, questionnaire determining fiber effect | Soy fiber ↑ total fecal wet weight and water content compared with control.1 |
| Lo, 1986 (122) | Patients in the United States (n = 20) with hyperlipidemia, 27–70 y, 84–143% ideal body weight | Single blind, crossover | 10-wk baseline diets, two 9-wk treatments | 25 g/d | Starch (cookies) | Soy fiber (cookies) | Participants advised of possible side effects (abdominal bloating, flatus, eructation, ↑ stool bulk and urgency) | Soy fiber was well tolerated |
| Munoz, 1979 (126) | Healthy males in the United States (n = 10), 19–54 y | Crossover | 30-d basal diet, 28–30 d/treatment (each fiber consumed by 4–6 males) | 26 g/d | None (basal diet) | Soybean hulls, 87% (basal diet) | Fecal weight | Mean daily fecal weight ↑ with soybean hulls compared with baseline.1 |
| Slavin, 1985 (127) | Healthy males in the United States (n = 16), 20–34 y | Randomized, 4-period crossover | 4 treatments, 10 d each | 30, 60 g/d | None (Ensure) | Soy fiber (Ensure and heat-treated Enrich) | Stool weight, transit time | Mean stool weights on Enrich + 30 g/d soy fiber, Ensure + 30 g/d, and Ensure + 60 g/d were 114.6, 100.2, and 150.3 g/d, respectively. Transit time was ↑ with Ensure alone (72.4 h) compared with fiber and self-selected diets (∼48 h).1 Soy fiber's effect on laxation was not affected by heat processing |
1
Differences were statistically significant (P ≤ 0.05).