TABLE 1.
Demographics and clinical characteristics by groups
| CHARACTERISTICS | PD (N=41) | ILBD (N=47) | CONTROL (N=137) | P-VALUE |
|---|---|---|---|---|
| Female, n (%) | 0.056 1 | |||
| Yes | 14 (34.1%) | 21 (44.7%) | 75 (54.7%) | N/A |
| Ever smoked, n (%) | 0.140 1 | |||
| Yes | 12 (29.3%) | 22 (46.8%) | 63 (46.0%) | N/A |
| UPSIT interval (from UPSIT to expiration; years) | 0.946 2 | |||
| Mean (SD) | 2.6 (2.5) | 2.5 (1.5) | 2.6 (2.4) | N/A |
| Range | 0.3, 10.0 | 0.1, 7.0 | 0.1, 15.9 | N/A |
| Age at smell test (years) | <0.001 2 | |||
| Mean (SD) | 80.2 (7.4) | 86.4 (6.3) | 84.8 (7.1) | N/A |
| Age at death (years) | <0.001 2 | |||
| Mean (SD) | 83.2 (7.7) | 89.4 (6.8) | 87.9 (7.0) | N/A |
| Olfactory bulb and tract aSyn density | <0.001 3 | |||
| N (Missing) | 39 (2) | 47 (0) | 137 (0) | N/A |
| Mean (SD) | 3.5 (0.8) | 2.5 (1.5) | 0.0 (0.0) | N/A |
| Amygdala aSyn density | <0.001 3 | |||
| N (Missing) | 41 (0) | 47 (0) | 137 (0) | N/A |
| Mean (SD) | 3.6 (0.7) | 1.5 (1.6) | 0.0 (0.0) | N/A |
| Transentorhinal aSyn density | <0.001 3 | |||
| N (Missing) | 40 (1) | 47 (0) | 137 (0) | N/A |
| Mean (SD) | 2.8 (1.0) | 0.5 (1.1) | 0.0 (0.0) | N/A |
| Unified Lewy body stage, n (%) | <0.001 1 | |||
| 0 | 0 (0.0%) | 0 (0.0%) | 137 (100.0%) | N/A |
| I | 0 (0.0%) | 5 (10.6%) | 0 (0.0%) | N/A |
| IIa | 4 (9.8%) | 24 (51.1%) | 0 (0.0%) | N/A |
| IIb | 1 (2.4%) | 4 (8.5%) | 0 (0.0%) | N/A |
| III | 19 (46.3%) | 13 (27.7%) | 0 (0.0%) | N/A |
| IV | 17 (41.5%) | 1 (2.1%) | 0 (0.0%) | N/A |
1Chi-squared p-value
2ANOVA F-test p-value
3Kruskal-Wallis p-value
PD: Parkinson’s disease; ILBD: incidental Lewy body disease; N/A: not applicable; UPSIT: University of Pennsylvania Smell Identification Test; SD: standard deviation; aSyn: Lewy type synucleinopathy