Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Dec 13;14(24):6137. doi: 10.3390/cancers14246137

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Effects of docetaxel (DTX) vs. LNP_DTX-P on in vivo tumour tissues. (A) Amounts of gold nanoparticles (GNPs) per gram of tumour tissue in untreated tissues, tissues treated with free DTX, tissues treated with LNP_DTX-1, and tissues treated with LNP_DTX-2 over time. ** indicates p < 0.01, *** indicates p < 0.001. (B) Cell cycle assay for untreated tumour tissue, tissue treated with free DTX, tissue treated with LNP_DTX-1, and tissue treated with LNP_DTX-2 over time. (C) Darkfield images of 4 µm sections of untreated tumour tissues, tissues treated with free DTX, and tissues treated with LNP_DTX-1. Scale bar: 40 µm. (D) Treatment of MIA PaCa-2 subcutaneous tumour with free docetaxel (DTX) vs. LNP_DTX-P. Hematoxylin and eosin stained sections of tumour tissues 0 h, 24 h, and 48 h after dosing with the drugs and GNPs. Scale bar: 80 µm.

Effects of docetaxel (DTX) vs. LNP_DTX-P on in vivo tumour tissues. (A) Amounts of gold nanoparticles (GNPs) per gram of tumour tissue in untreated tissues, tissues treated with free DTX, tissues treated with LNP_DTX-1, and tissues treated with LNP_DTX-2 over time. ** indicates p < 0.01, *** indicates p < 0.001. (B) Cell cycle assay for untreated tumour tissue, tissue treated with free DTX, tissue treated with LNP_DTX-1, and tissue treated with LNP_DTX-2 over time. (C) Darkfield images of 4 µm sections of untreated tumour tissues, tissues treated with free DTX, and tissues treated with LNP_DTX-1. Scale bar: 40 µm. (D) Treatment of MIA PaCa-2 subcutaneous tumour with free docetaxel (DTX) vs. LNP_DTX-P. Hematoxylin and eosin stained sections of tumour tissues 0 h, 24 h, and 48 h after dosing with the drugs and GNPs. Scale bar: 80 µm.