Table 1.
Adipose expression (mRNA) of TLRs, their downstream signaling mediators, IRFs, and SRA1 in participants with and without T2D.
| Inflammatory Marker | Total Participants (N = 108) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Without T2D (N = 55) | With T2D (N = 53) | ||||||||||
| Normal Weight (N = 8) | Overweight (N = 19) | Obese (N = 28) |
Normal Weight vs. Overweight (p Value) # |
Normal Weight vs. Obese (p Value) # |
Normal Weight (N = 4) | Overweight (N = 13) |
Obese (N = 36) |
Normal Weight vs. Overweight (p Value) # |
Normal Weight vs. Obese (p Value) # | Without T2D (N = 55) vs. With T2D (N = 53) (p Value) $ | |
| SRA1 | 1.7 ± 0.24 | 1.8 ± 0.61 | 2.2 ± 0.62 | 0.335 | 0.025 * | 2.3 ± 0.95 | 1.7 ± 0.55 | 1.9 ± 1.17 | 0.175 | 0.436 | 0.373 |
| TLR2 | 1.95 ± 1.04 | 2.88 ± 1.96 | 3.20 ± 1.31 | 0.197 | 0.018 * | 2.18 ± 0.76 | 2.82 ± 1.17 | 3.27 ± 1.66 | 0.465 | 0.272 | 0.305 |
| TLR3 | 1.49 ± 0.30 | 1.79 ± 1.17 | 2.57 ± 1.50 | 0.629 | 0.019 * | 3.24 ± 2.20 | 1.74 ± 1.06 | 2.07 ± 0.59 | 0.168 | 0.616 | 0.618 |
| TLR4 | 1.31 ± 0.23 | 1.42 ± 0.41 | 1.67 ± 0.65 | 0.661 | 0.267 | 2.04 ± 0.89 | 1.33 ± 0.31 | 1.57 ±0.45 | 0.144 | 0.441 | 0.609 |
| TLR7 | 2.06 ± 0.83 | 3.15 ± 2.27 | 3.38 ± 2.17 | 0.502 | 0.141 | 2.89 ± 1.51 | 1.92 ± 1.36 | 3.78 ± 2.04 | 0.387 | 0.638 | 0.546 |
| TLR8 | 1.68 ± 0.69 | 3.51 ± 2.90 | 3.31 ± 1.96 | 0.117 | 0.061 * | 2.85 ± 0.75 | 2.71 ± 1.60 | 3.94 ± 2.78 | 0.776 | 0.655 | 0.202 |
| TLR9 | 8.51 ± 3.91 | 7.85 ± 3.37 | 7.32 ± 3.87 | 0.803 | 0.292 | 7.02 ± 5.62 | 7.63 ± 2.54 | 7.91 ± 3.47 | 0.379 | 0.357 | 0.852 |
| TLR10 | 21.88 ± 22.28 | 23.04 ± 22.15 | 29.88 ± 37.15 | 0.719 | 0.549 | 24.96 ± 15.52 | 23.97 ± 24.62 | 23.05 ± 20.07 | 0.625 | 0.65 | 0.976 |
| NF-κB | 1.18 ± 0.20 | 1.28 ± 0.33 | 1.38 ± 0.28 | 0.476 | 0.053 | 1.47 ± 0.29 | 1.28 ± 0.42 | 1.26 ± 0.37 | 0.342 | 0.282 | 0.559 |
| MyD88 | 1.62 ± 0.47 | 1.86 ± 0.73 | 1.85 ± 0.57 | 0.421 | 0.346 | 2.71 ± 0.77 | 1.96 ± 0.57 | 1.92 ± 0.59 | 0.166 | 0.112 | 0.240 |
| IRAK1 | 6.14 ± 2.83 | 8.19 ± 3.37 | 9.12 ± 3.28 | 0.119 | 0.042 * | 8.01 ± 1.11 | 9.45 ± 3.46 | 9.69 ± 3.23 | 0.432 | 0.353 | 0.116 |
| TRAF6 | 2.49 ± 0.35 | 2.26 ± 1.18 | 2.36 ± 0.98 | 0.113 | 0.255 | 2.12 ± 0.80 | 2.26 ± 0.75 | 2.33 ± 0.64 | 0.922 | 0.712 | 0.544 |
| IRF3 | 1.81 ± 0.57 | 2.31 ± 0.68 | 2.54 ± 0.61 | 0.152 | 0.065 | 2.45 ± 0.80 | 2.73 ± 0.56 | 2.65 ± 0.59 | 0.4542 | 0.675 | 0.047 * |
| IRF4 | 2.21 ± 0.84 | 3.61 ± 2.18 | 3.40 ± 1.99 | 0.228 | 0.169 | 3.74 ± 3.41 | 4.32 ± 2.10 | 3.95 ±1.46 | 0.702 | 0.828 | 0.020 * |
| IRF5 | 1.53 ± 0.33 | 2.82 ± 1.44 | 2.73 ± 1.08 | 0.027 * | 0.016 * | 2.72 ± 0.93 | 2.90 ± 1.31 | 3.13 ±1.13 | 0.879 | 0.584 | 0.039 * |
# = One way Anova, Kruskal-Wallis test, $ = Mann-Whitney test. * Significant.