Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Dec 12;11(24):4013. doi: 10.3390/cells11244013

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Decreased immune response in DNAH5-mutated organoids. (A) GO enrichment analysis of biological processes in DNAH5-mutated and normal airway organoids. The immune responses were downregulated in DNAH5-mutated airway organoids (left), whereas epithelial cell differentiation was downregulated (right). (B) The heatmap illustrates the expression level changes of the statistically significant proteins related to the adaptive immune response, innate immune response and epithelial development between DNAH5-mutated and normal airway organoids. (C) Stepwise protocol for airway organoids infected by RSV. (D) The copies of RSV-N detected by ddPCR confirming the different infections between DNAH5-mutated and normal airway organoids. * p < 0.05; n = 3 replicates. (E) The expression of immune factors in DNAH5-mutated and normal airway organoids infected by RSV at 48 hpi. **** p < 0.0001; n = 3 replicates.