Table 1.
Case summaries of three patients with Peyronie’s disease treated with combined multimodal therapy.
| No. | Patient Age | Associated Disease | Penile Plaque Site | Ultrasound Measurements (Length × Width × Thickness) and Plaque Volume before (A) and after Treatment (B) | Type of Deformity Initial (A) and after Treatment (B) |
Pain Score/VAS Scale (1–10) | IIEF Score before and after Treatment | Total Duration of Treatment until Plaque Regression | Complete Combined Multimodal Treatment |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 31 years | Chronic prostatitis and associated anxious and depressive state. | Distal third | (A) 15.1 × 12.1 × 3.7 mm volume = 353 mm3 (B) No plaque detected |
(A) 10-degree ventral curvature + 15-degree left curvature (B) None |
VAS score = 8 Pain disappeared after 12 months |
26 > 27 | 30 months | Orally: propolis 600 mg + bilberry 160 mg + silymarin 400 mg + ginkgo biloba 250 mg + L-carnitine 1000 mg + coenzyme Q10 100 mg + Boswellia 200 mg + Vitamin E 30 mg/daily/for 30 months + topically: diclofenac gel 4%/2× daily for 30 months Note: The patient refused periplaque penile injections with pentoxifylline |
| 2 | 52 years | Dupuytren’s disease, Ledderhose disease, congenital dorsal penile curvature (5 degrees). |
Middle third + distal third |
(A) First plaque: 13.4 × 9.15 × 2.83 mm volume = 182 mm3. Second plaque: 14.8 × 8.43 × 3.87 mm. Total volume = 252 mm3 (B) No plaque detected |
(A) 20-degree dorsal penile curvature + 20-degree left penile curvature (B) 5-degree dorsal penile curvature. Previous condition = congenital dorsal penile curvature (5 degrees) |
VAS score = 0 |
26 > 27 | 51 months | Orally: propolis 600 mg + bilberry 160 mg + silymarin 400 mg + ginkgo biloba 250 mg + L-carnitine 1000 mg + coenzyme Q10 100 mg + Boswellia 200 mg + vitamin E 30 mg/daily for 51 months + topically: diclofenac gel 4%/2× daily for 51 months + periplaque penile injections: pentoxifylline 100 mg (30 G needle) every 2 weeks for 6 months, and then 1 penile injection every month for 12 months, and 1 penile injection every 2 months for 24 months (42 total injections) |
| 3 | 30 years | Left varicocele | Proximal third | (A) 12.2 × 11.2 × 2.81 mm volume = 203 mm3 (B) No plaque detected |
(A) No penile deformation (B) No penile deformation |
VAS score = 5 Pain disappeared after 4 months |
26 > 26 | 4 months | Orally: propolis 600 mg + bilberry 160 mg + silymarin 400 mg + ginkgo biloba 250 mg + vitamin E 800 IU/daily for 4 months + topically: diclofenac gel 4%/2× daily for 4 months Note: Penile injections not needed |
Abbreviations: IIEF = International Index of Erectile Function; VAS = visual analog pain score.