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. 2022 Dec 13;11(24):4031. doi: 10.3390/cells11244031

Figure 2.

Figure 2

FUT2 promotes the autophagy of lung adenocarcinoma cells. (A) Representative Western blot showing the expressions of FUT2 and LC3-II in diverse lung cancer cell lines (A549, H1299, H460) and Beas-2b cells. (B,C) Representative RT-qPCR and Western blot showing successful constructions of RNAi-FUT2 A549 cells. (D) Representative Western blot showing that knockdown of FUT2 inhibited the expressions of Beclin1, Atg5, p62, and LC3-II in A549 and H1299 cells. (E) Representative RT-qPCR showing that the knockdown of FUT2 decreased the mRNA expression of LC3, Beclin1, and p62 in A549 cells. (F) Representative Western blot showing that the upregulation of FUT2 expression promoted the expressions of Atg5 and LC3-II in A549 cells. (G) Representative Western blot showing that the upregulation of FUT2 expression promoted the expressions of LC3-II, p62, and Atg5 in H460 cells. (H) Representative Western blot showing that the knockdown of FUT2 inhibited the expressions of LC3-II and p62 in tumors (* p < 0.05, ** p < 0.01, and *** p < 0.001).