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Interactions between α-syn and NKA α subunit in the extracellular and intracellular segments. Left panel: α-syn bound to the neuronal membrane and formed a complex with NKAα3. This complex impaired NKAα3 activity and increased glutamate-induced Ca2+ influx to induce neuronal loss. Right panel: Intracellular part of NKAα1 formed a complex with α-syn/AMPKα to translocate AMPKα to the plasma membrane. DR5-12D prevented the formation of this complex and alleviated the symptoms of PD.
