Table 1.
Studies of preoperative radiotherapy in breast cancer.
| Author | n | Inclusion Criteria | RT | % pCR | Number of Local Recurrences |
DFS (%) | OS (%) | Skin Complications |
MFU (Months) |
|---|---|---|---|---|---|---|---|---|---|
| Semiglazov et al., 1994 [23] | 134 | IIB–IIIA | 60 Gy/2 Gy/30 fractions; SCF 40 Gy/2 Gy/20 fractions | 19.4% | NS | 5y DFS: 71.6 | 5y OS: 78.3 | G2: 8.9% | 53 |
| Calitchi et al., 2001 [24] | 75 | T2–T3 | 45 Gy/1.8 Gy/25 fractions whole breast, lower axillary nodes | 11% | 9 | 10y DFS: 47 | 10y OS: 55 | 6% poor cosmetic results | 120 (10 years) |
| Riet et al., 2017 [25] | 187 | T2–T4 | 45 Gy/2.5 Gy/18 fractions | 10% (26% in TN tumors) |
15 | 25y DFS: 30 | 25y OS: 30 | Post-operative G ≥ 2: 19% | 384 (32 years) |
MFU: median follow-up.