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. Author manuscript; available in PMC: 2022 Dec 22.
Published in final edited form as: FASEB J. 2021 May;35(5):e21606. doi: 10.1096/fj.202100203R

Figure 6. Enhanced NKCC1 expression does not support increased capacity for stimulated Cl− secretion.

Figure 6.

ISC (A) and GTE (B) measurements from normal (open circles) and dietary Na+ depleted (closed circles) rat distal colon, as well as dietary Na+-depleted rat distal colon pre-treated with mucosal IbTX (250 nM) (grey triangles) in the presence of mucosal 100 μM amiloride. Tissues were treated with 10 μM forskolin (FSK) in the serosal bath where indicated. (C-D) Group data showing change in (Δ) ISC (C) and GTE (D) induced by FSK in each group. Average ISC and GTE values over the course of 1 minute immediately prior to FSK addition, and 1 minute at the end of the recording period were calculated for each tissue. ΔISC and ΔGTE were calculated by subtracting the basal value from the value at the end of the recording period, after FSK addition. Lines and error bars represent means ± SEM.